Mitochondrial Uptake of Thiamin Pyrophosphate: Physiological and Cell Biological Aspects

@inproceedings{Subramanian2013MitochondrialUO,
  title={Mitochondrial Uptake of Thiamin Pyrophosphate: Physiological and Cell Biological Aspects},
  author={V. Sankara Subramanian and Svetlana M. Nabokina and Yaping Lin-Moshier and Jonathan S. Marchant and Hamid Said},
  booktitle={PloS one},
  year={2013}
}
Mammalian cells obtain vitamin B1 (thiamin) from their surrounding environment and convert it to thiamin pyrophosphate (TPP) in the cytoplasm. Most of TPP is then transported into the mitochondria via a carrier-mediated process that involves the mitochondrial thiamin pyrophosphate transporter (MTPPT). Knowledge about the physiological parameters of the MTPP-mediated uptake process, MTPPT targeting and the impact of clinical mutations in MTPPT in patients with Amish lethal microcephaly and… CONTINUE READING
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