Mitochondrial Uncoupling Protein-2 (UCP2) Mediates Leptin Protection Against MPP+ Toxicity in Neuronal Cells

@inproceedings{Ho2009MitochondrialUP,
  title={Mitochondrial Uncoupling Protein-2 (UCP2) Mediates Leptin Protection Against MPP+ Toxicity in Neuronal Cells},
  author={Philip Ho and H W Liu and Jessica Wing-Man Ho and Wei-yi Zhang and Andrew Chi-Yuen Chu and Ken Hon-Hung Kwok and Xuan Ge and Koon Ho Chan and David Boyer Ramsden and Shu Leong Ho},
  booktitle={Neurotoxicity Research},
  year={2009}
}
Mitochondrial dysfunction is involved in the pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD). Uncoupling proteins (UCPs) delink ATP production from biofuel oxidation in mitochondria to reduce oxidative stress. UCP2 is expressed in brain, and has neuroprotective effects under various toxic insults. We observed induction of UCP2 expression by leptin in neuronal cultures, and hypothesize that leptin may preserve neuronal survival via UCP2. We showed that leptin… CONTINUE READING
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