Mitochondrial Substrate Level Phosphorylation Is Essential for Growth of Procyclic Trypanosoma brucei *

@article{BochudAllemann2002MitochondrialSL,
  title={Mitochondrial Substrate Level Phosphorylation Is Essential for Growth of Procyclic Trypanosoma brucei *},
  author={Natacha Bochud-Allemann and A. Schneider},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={32849 - 32854}
}
Oxidative phosphorylation and substrate level phosphorylation catalyzed by succinyl-CoA synthetase found in the citric acid and the acetate:succinate CoA transferase/succinyl-CoA synthetase cycle contribute to mitochondrial ATP synthesis in procyclicTrypanosoma brucei. The latter pathway is specific for trypanosome but also found in hydrogenosomes. In organelloATP production was studied in wild-type and in RNA interference cell lines ablated for key enzymes of each of the three pathways. The… Expand
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