Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPRmt

@article{Tian2016MitochondrialSI,
  title={Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPRmt},
  author={Ye Tian and Gilberto Garcia and Qian Bian and Kristan K. Steffen and Larry Joe and Suzanne C. Wolff and Barbara J Meyer and Andrew G Dillin},
  journal={Cell},
  year={2016},
  volume={165},
  pages={1197-1208}
}
Organisms respond to mitochondrial stress through the upregulation of an array of protective genes, often perpetuating an early response to metabolic dysfunction across a lifetime. We find that mitochondrial stress causes widespread changes in chromatin structure through histone H3K9 di-methylation marks traditionally associated with gene silencing… CONTINUE READING