Mitochondrial Signaling in Mammalian Cells Activated by Red and Near‐IR Radiation

@article{Karu2008MitochondrialSI,
  title={Mitochondrial Signaling in Mammalian Cells Activated by Red and Near‐IR Radiation},
  author={Tiina I. Karu},
  journal={Photochemistry and Photobiology},
  year={2008},
  volume={84}
}
  • T. Karu
  • Published 1 September 2008
  • Biology
  • Photochemistry and Photobiology
Mitochondrial signaling is an information channel between the mitochondrial respiratory chain and the nucleus for the transduction signals regarding the functional state of the mitochondria. The present review examines the question whether radiation of visible and near‐IR (IR‐A) radiation can activate this retrograde‐type cellular signaling pathway. Experimental data about modulation of elements of mitochondrial retrograde signaling by the irradiation (mitochondrial membrane potential ΔΨm… 
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References

SHOWING 1-10 OF 125 REFERENCES
Mitochondrial signaling: the retrograde response.
Mitochondrial reactive oxygen species-mediated signaling in endothelial cells.
TLDR
Findings that indicate that mitochondrial ROS regulate vascular endothelial function are discussed, focusing on major sites of ROS production in endothelial mitochondria, factors modulating mitochondrial ROS production, the physiological and clinical implications of endothelial mitochondrial ROS, and methodological considerations in the study of mitochondrial contribution to vascular ROS generation.
Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species.
Mitochondrial signaling, TOR, and life span
TLDR
A brief review of the recent progress on how mitochondrial signaling might contribute to the aging process with a particular emphasis on TOR signaling from invertebrates to humans is summarized.
Mitochondrial retrograde signaling.
TLDR
Advances in the yeast retrograde signaling pathway are reviewed and its regulatory factors and regulatory mechanisms, its physiological functions, and its connection to nutrient sensing, TOR signaling, and aging are highlighted.
A mitochondrial oscillator dependent on reactive oxygen species.
TLDR
A computational model of mitochondrial energetics and Ca(2+) handling reproduces the period and phase of the observed oscillations in Delta Psi(m), NADH, and ROS, and experimentally verify model predictions that the period of the oscillator can be modulated by altering the concentration of ROS scavengers or the rate of oxidative phosphorylation.
Nitric oxide and mitochondrial biogenesis
TLDR
No-induced mitochondrial biogenesis seems to be linked to proliferation and differentiation of normal and tumor cells, as well as in aging, and may have far-reaching implications in development, aging, disease and environmental adaptation.
Synchronized Whole Cell Oscillations in Mitochondrial Metabolism Triggered by a Local Release of Reactive Oxygen Species in Cardiac Myocytes*
TLDR
The transitions in mitochondrial energetics were tightly coupled to activation of sarcolemmal KATP currents, causing oscillations in action potential duration, and thus might contribute to catastrophic arrhythmias during ischemia-reperfusion injury.
A Novel Mitochondrial Signaling Pathway Activated by Visible-to-near Infrared Radiation¶
TLDR
Comparison of action spectra allows the conclusions that first, CuA and CuB chromophores of cytochrome c oxidase could be involved as photoacceptors and second, various signaling pathways (reaction channels) between cy tochrome c oxidation and cell attachment regulation are at work.
Cellular response to infrared radiation involves retrograde mitochondrial signaling.
...
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2
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4
5
...