Mitochondrial Respiratory Chain Dysfunction in Dorsal Root Ganglia of Streptozotocin-Induced Diabetic Rats and Its Correction by Insulin Treatment

@inproceedings{Chowdhury2010MitochondrialRC,
  title={Mitochondrial Respiratory Chain Dysfunction in Dorsal Root Ganglia of Streptozotocin-Induced Diabetic Rats and Its Correction by Insulin Treatment},
  author={Subir Chowdhury and Elena Zherebitskaya and Darrell R. Smith and Eli Akude and Sharmila Chattopadhyay and Corinne G. Jolivalt and Nigel A. Calcutt and Paul Fernyhough},
  booktitle={Diabetes},
  year={2010}
}
OBJECTIVE Impairments in mitochondrial physiology may play a role in diabetic sensory neuropathy. We tested the hypothesis that mitochondrial dysfunction in sensory neurons is due to abnormal mitochondrial respiratory function. RESEARCH DESIGN AND METHODS Rates of oxygen consumption were measured in mitochondria from dorsal root ganglia (DRG) of 12- to- 22-week streptozotocin (STZ)-induced diabetic rats, diabetic rats treated with insulin, and age-matched controls. Activities and expression… CONTINUE READING