Mitochondrial Respiratory Capacity and Content Are Normal in Young Insulin-Resistant Obese Humans

@inproceedings{FisherWellman2014MitochondrialRC,
  title={Mitochondrial Respiratory Capacity and Content Are Normal in Young Insulin-Resistant Obese Humans},
  author={Kelsey H. Fisher-Wellman and Todd M. Weber and Brook L. Cathey and Patricia M. Brophy and Laura A.A. Gilliam and Constance L. Kane and Jill M. Maples and Timothy P. Gavin and Joseph A. Houmard and P. Darrell Neufer},
  booktitle={Diabetes},
  year={2014}
}
Considerable debate exists about whether alterations in mitochondrial respiratory capacity and/or content play a causal role in the development of insulin resistance during obesity. The current study was undertaken to determine whether such alterations are present during the initial stages of insulin resistance in humans. Young (∼23 years) insulin-sensitive lean and insulin-resistant obese men and women were studied. Insulin resistance was confirmed through an intravenous glucose tolerance test… CONTINUE READING
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