Mitochondrial Rac1 GTPase Import and Electron Transfer from Cytochrome c Are Required for Pulmonary Fibrosis*

  title={Mitochondrial Rac1 GTPase Import and Electron Transfer from Cytochrome c Are Required for Pulmonary Fibrosis*},
  author={Heather L Osborn-Heaford and Alan J Ryan and Shubha Murthy and A-M. Racila and Chao He and Jessica C. Sieren and Douglas R. Spitz and A. Brent Carter},
  journal={The Journal of Biological Chemistry},
  pages={3301 - 3312}
Background: Rac1 activation is linked to H2O2 generation in macrophages. Results: Two cysteine residues in Rac1 modulate mitochondrial H2O2 generation via import and electron transfer from cytochrome c. Conclusion: Mitochondrial Rac1 activity in alveolar macrophages is associated with oxidative stress. Significance: Rac1 directly mediates mitochondrial H2O2 production in alveolar macrophages, which is linked to pulmonary fibrosis. The generation of reactive oxygen species, particularly H2O2… 

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