Mitochondrial ROS-mediated post-transcriptional regulation of α-synuclein through miR-7 and miR-153.


Dysregulation of human alpha-synuclein (α-SYN) is one of the major contributors in the pathogenesis of Parkinson's disease. 1-methyl-4-phenylpyridinium (MPP+) is well known neurotoxin which increases α-SYN expression and causes dopaminergic neuronal death. Increasing evidence suggests microRNAs (miRNAs), especially miRNA-7 and miR-153, have important role… (More)
DOI: 10.1016/j.neulet.2017.09.065