Mitochondrial ROS-induced ROS release: an update and review.

  title={Mitochondrial ROS-induced ROS release: an update and review.},
  author={Dmitry B. Zorov and Magdalena Juhaszova and Steven J. Sollott},
  journal={Biochimica et biophysica acta},
  volume={1757 5-6},
Unstable mitochondrial membrane potential and redox transitions can occur following insults including ischemia/reperfusion injury and toxin exposure, with negative consequences for mitochondrial integrity and cellular survival. These transitions can involve mechanisms such as the recently described process, "Reactive Oxygen Species (ROS)-induced ROS-release" (RIRR), and be generated by circuits where the mitochondrial permeability transition (MPT) pore and the inner membrane anion channel (IMAC… CONTINUE READING
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