Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan.

  title={Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan.},
  author={Filippo Scial{\'o} and Ashwin Sriram and Daniel Jos{\'e} Moreno Fern{\'a}ndez-Ayala and N. E. Gubina and Madis L{\~o}hmus and Glyn Nelson and Angela Logan and Helen M. Cooper and Pl{\'a}cido Navas and Jos{\'e} Antonio Enr{\'i}quez and Michael P Murphy and Alberto Hernando Sanz},
  journal={Cell metabolism},
  volume={23 4},
Increased production of reactive oxygen species (ROS) has long been considered a cause of aging. However, recent studies have implicated ROS as essential secondary messengers. Here we show that the site of ROS production significantly contributes to their apparent dual nature. We report that ROS increase with age as mitochondrial function deteriorates. However, we also demonstrate that increasing ROS production specifically through respiratory complex I reverse electron transport extends… CONTINUE READING
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