Mitochondrial RNA polymerase is an essential enzyme in erythrocytic stages of Plasmodium falciparum.

@article{Ke2012MitochondrialRP,
  title={Mitochondrial RNA polymerase is an essential enzyme in erythrocytic stages of Plasmodium falciparum.},
  author={Hangjun Ke and Joanne M. Morrisey and Suresh Ganesan and Michael W. Mather and Akhil B. Vaidya},
  journal={Molecular and biochemical parasitology},
  year={2012},
  volume={185 1},
  pages={48-51}
}
We have shown that transgenic Plasmodium falciparum parasites expressing the yeast DHODH (dihydroorotate dehydrogenase) are independent of the mtETC (mitochondrial electron transport chain), suggesting that they might not need the mitochondrial genome (mtDNA), since it only encodes three protein subunits belonging to the mtETC and fragmentary ribosomal RNA molecules. Disrupting the mitochondrial RNA polymerase (mtRNAP), which is critical for mtDNA replication and transcription, might then cause… CONTINUE READING

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