Mitochondrial Quality Control as a Therapeutic Target.

  title={Mitochondrial Quality Control as a Therapeutic Target.},
  author={Hagir B. Suliman and Claude A. Piantadosi},
  journal={Pharmacological reviews},
  volume={68 1},
In addition to oxidative phosphorylation (OXPHOS), mitochondria perform other functions such as heme biosynthesis and oxygen sensing and mediate calcium homeostasis, cell growth, and cell death. They participate in cell communication and regulation of inflammation and are important considerations in aging, drug toxicity, and pathogenesis. The cell's capacity to maintain its mitochondria involves intramitochondrial processes, such as heme and protein turnover, and those involving entire… CONTINUE READING
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