Mitochondrial Preprotein Translocase of Trypanosomatids Has a Bacterial Origin

@article{Pusnik2011MitochondrialPT,
  title={Mitochondrial Preprotein Translocase of Trypanosomatids Has a Bacterial Origin},
  author={M. Pusnik and O. Schmidt and A. Perry and S. Oeljeklaus and M. Niemann and B. Warscheid and T. Lithgow and C. Meisinger and A. Schneider},
  journal={Current Biology},
  year={2011},
  volume={21},
  pages={1738-1743}
}
Mitochondria are found in all eukaryotic cells and derive from a bacterial endosymbiont [1, 2]. The evolution of a protein import system was a prerequisite for the conversion of the endosymbiont into a true organelle. Tom40, the essential component of the protein translocase of the outer membrane, is conserved in mitochondria of almost all eukaryotes but lacks bacterial orthologs [3-6]. It serves as the gateway through which all mitochondrial proteins are imported. The parasitic protozoa… Expand
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