Mitochondrial PKC and MAPK Form Signaling Modules in the Murine Heart Enhanced Mitochondrial PKC-MAPK Interactions and Differential MAPK Activation in PKC-Induced Cardioprotection

@inproceedings{Baines2002MitochondrialPA,
  title={Mitochondrial PKC and MAPK Form Signaling Modules in the Murine Heart Enhanced Mitochondrial PKC-MAPK Interactions and Differential MAPK Activation in PKC-Induced Cardioprotection},
  author={Christopher P. Baines and Jun Zhang and G Wang and Yu-Ting Zheng and Joanne X. Xiu and Ernest M. Cardwell and Roberto Bolli and Peipei Ping},
  year={2002}
}
Although activation of protein kinase C (PKC) and mitogen-activated protein kinases (MAPKs) are known to play crucial roles in the manifestation of cardioprotection, the spatial organization of PKC signaling modules in naïve and protected myocardium remains unknown. Based on evidence that mitochondria are key mediators of the cardioprotective signal, we hypothesized that PKC and MAPKs interact, and that they form functional signaling modules in mitochondria during cardioprotection. Both… CONTINUE READING

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