Mitochondrial Oxidation in Rat Hippocampus Can Be Preconditioned by Selective Chemical Inhibition of Succinic Dehydrogenase

@article{Riepe1996MitochondrialOI,
  title={Mitochondrial Oxidation in Rat Hippocampus Can Be Preconditioned by Selective Chemical Inhibition of Succinic Dehydrogenase},
  author={Matthias Riepe and W. N. Niemi and Dirk Megow and Albert Christian Ludolph and David O Carpenter},
  journal={Experimental Neurology},
  year={1996},
  volume={138},
  pages={15-21}
}
Repeatedly it was reported that a short ischemic episode may ameliorate biochemical and morphological impairment upon succeeding severe ischemia. We investigated whether the pattern of respiratory enzyme activity (RA), adenine nucleotides, and membrane potential in hippocampal slices following low-dose in vivo (20 mg/kg) and high-dose in vitro (1 mM) application of 3-nitropropionic acid (3-np), a specific inhibitor of succinic dehydrogenase (SDH), indicates a similar tolerance phenomenon. One… CONTINUE READING
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