Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting.

  title={Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting.},
  author={Arnaud Chevalier and Yanmin Zhang and Omar M Khdour and Justin B Kaye and Sidney M Hecht},
  journal={Journal of the American Chemical Society},
  volume={138 37},
Nitroreductase (NTR) activities have been known for decades, studied extensively in bacteria and also in systems as diverse as yeast, trypanosomes, and hypoxic tumors. The putative bacterial origin of mitochondria prompted us to explore the possible existence of NTR activity within this organelle and to probe its behavior in a cellular context. Presently, by using a profluorescent near-infrared (NIR) dye, we characterize the nature of NTR activity localized in mammalian cell mitochondria… CONTINUE READING
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