Mitochondrial Morphology and Mitophagy in Heart Diseases: Qualitative and Quantitative Analyses Using Transmission Electron Microscopy

  title={Mitochondrial Morphology and Mitophagy in Heart Diseases: Qualitative and Quantitative Analyses Using Transmission Electron Microscopy},
  author={Helen E Collins and Mariame Selma Kane and Silvio Litovsky and Victor Darley-Usmar and Martin E. Young and John C. Chatham and Jianhua Zhang},
  journal={Frontiers in Aging},
Transmission electron microscopy (TEM) has long been an important technique, capable of high degree resolution and visualization of subcellular structures and organization. Over the last 20 years, TEM has gained popularity in the cardiovascular field to visualize changes at the nanometer scale in cardiac ultrastructure during cardiovascular development, aging, and a broad range of pathologies. Recently, the cardiovascular TEM enabled the studying of several signaling processes impacting… 

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  • 2019

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    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • 2015

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Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes*

A novel and essential role of MFN2 is revealed in the cardiac autophagic process by mediating the maturation of autophagy at the phase ofAutophagosome-lysosome fusion, which was markedly retarded without altering the formation of Autophagy and lysosomes in response to ischemia-reperfusion stress.

Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy.

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