Mitochondrial Machineries for Protein Import and Assembly.

@article{Wiedemann2017MitochondrialMF,
  title={Mitochondrial Machineries for Protein Import and Assembly.},
  author={Nils Wiedemann and Nikolaus Pfanner},
  journal={Annual review of biochemistry},
  year={2017},
  volume={86},
  pages={
          685-714
        }
}
Mitochondria are essential organelles with numerous functions in cellular metabolism and homeostasis. Most of the >1,000 different mitochondrial proteins are synthesized as precursors in the cytosol and are imported into mitochondria by five transport pathways. The protein import machineries of the mitochondrial membranes and aqueous compartments reveal a remarkable variability of mechanisms for protein recognition, translocation, and sorting. The protein translocases do not operate as separate… CONTINUE READING
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