Mitochondrial JNK phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage

@article{Nijboer2013MitochondrialJP,
  title={Mitochondrial JNK phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage},
  author={Cora H. A. Nijboer and Hilde J C Bonestroo and Jitske Zijlstra and Annemieke Kavelaars and Cobi J Heijnen},
  journal={Neurobiology of Disease},
  year={2013},
  volume={54},
  pages={432-444}
}
Neonatal encephalopathy is associated with high mortality and life-long developmental consequences. Therapeutic options are very limited. We assessed the effects of D-JNKi, a small peptide c-Jun N-terminal kinase (JNK) MAP kinase inhibitor, on neuroinflammation, mitochondrial integrity and neuronal damage in a neonatal rat model of ischemic brain damage. Hypoxic-ischemic (HI) brain injury was induced in postnatal-day 7 rats by unilateral carotid artery occlusion and hypoxia, and was followed by… CONTINUE READING

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