Mitochondrial Glutathione: A Modulator of Brain Cell Death

@article{Sims2004MitochondrialGA,
  title={Mitochondrial Glutathione: A Modulator of Brain Cell Death},
  author={N. Sims and M. Nilsson and H. Muyderman},
  journal={Journal of Bioenergetics and Biomembranes},
  year={2004},
  volume={36},
  pages={329-333}
}
The small fraction of glutathione in mitochondria in nonneural tissues is an important contributor to cell survival under some conditions. However, there has been only limited characterization of the properties and function of mitochondrial glutathione in cells from the brain. In astrocytes in culture, highly selective depletion of this glutathione pool does not affect cell viability, at least in the first 24 h, but does greatly increase susceptibility to exposure to nitric oxide or… Expand
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