Mitochondrial Genome Maintenance 1 (Mgm1) Protein Alters Membrane Topology and Promotes Local Membrane Bending.

@article{Rujiviphat2015MitochondrialGM,
  title={Mitochondrial Genome Maintenance 1 (Mgm1) Protein Alters Membrane Topology and Promotes Local Membrane Bending.},
  author={Jarungjit Rujiviphat and Michael Sze Ka Wong and Amy Hye Won and Yu-Ling Shih and Christopher M Yip and G. Angus McQuibban},
  journal={Journal of molecular biology},
  year={2015},
  volume={427 16},
  pages={2599-609}
}
Large GTPases of the dynamin superfamily promote membrane fusion and division, processes that are crucial for intracellular trafficking and organellar dynamics. To promote membrane scission, dynamin proteins polymerize, wrap around, and constrict the membrane; however, the mechanism underlying their role in membrane fusion remains unclear. We previously reported that the mitochondrial dynamin-related protein mitochondrial genome maintenance 1 (Mgm1) mediates fusion by first tethering opposing… CONTINUE READING