Mitochondrial E3 ligase March5 maintains stemness of mouse ES cells via suppression of ERK signalling

Abstract

Embryonic stem cells (ESCs) possess pluripotency, which is the capacity of cells to differentiate into all lineages of the mature organism. Increasing evidence suggests that the pluripotent state of ESCs is regulated by a combination of extrinsic and intrinsic factors. The underlying mechanisms, however, are not completely understood. Here, we show that… (More)
DOI: 10.1038/ncomms8112

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