Mitochondrial Dysfunction in Pten Haplo-Insufficient Mice with Social Deficits and Repetitive Behavior: Interplay between Pten and p53

@inproceedings{Napoli2012MitochondrialDI,
  title={Mitochondrial Dysfunction in Pten Haplo-Insufficient Mice with Social Deficits and Repetitive Behavior: Interplay between Pten and p53},
  author={Eleonora Napoli and Catherine M Ross-Inta and Sarah Wong and Connie K Hung and Yasuko Fujisawa and Danielle Sakaguchi and James M. Angelastro and Alicja Omanska-Klusek and Robert E Schoenfeld and Cecilia Giulivi},
  booktitle={PloS one},
  year={2012}
}
Etiology of aberrant social behavior consistently points to a strong polygenetic component involved in fundamental developmental pathways, with the potential of being enhanced by defects in bioenergetics. To this end, the occurrence of social deficits and mitochondrial outcomes were evaluated in conditional Pten (Phosphatase and tensin homolog) haplo-insufficient mice, in which only one allele was selectively knocked-out in neural tissues. Pten mutations have been linked to Alzheimer's disease… CONTINUE READING
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