Mitochondrial Dysfunction in Congenital Nephrotic Syndrome

  title={Mitochondrial Dysfunction in Congenital Nephrotic Syndrome},
  author={M S Solin and Sari Pitk{\"a}nen and Jaan-Willem Taanman and Harry Holth{\"o}fer},
  journal={Laboratory Investigation},
The molecular mechanisms maintaining the kidney glomerular filtration barrier remain poorly understood. Recent evidence suggests that mitochondrial dysfunction is a characteristic feature of kidney glomeruli in congenital nephrotic syndrome of the Finnish type (CNF). Here we searched for detailed functional evidence of mitochondrial lesion in CNF kidneys… CONTINUE READING