Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect

@article{Veatch2009MitochondrialDL,
  title={Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect},
  author={Joshua Robert Veatch and Michael A McMurray and Zara W. Nelson and Daniel E Gottschling},
  journal={Cell},
  year={2009},
  volume={137},
  pages={1247-1258}
}
Mutations and deletions in the mitochondrial genome (mtDNA), as well as instability of the nuclear genome, are involved in multiple human diseases. Here, we report that in Saccharomyces cerevisiae, loss of mtDNA leads to nuclear genome instability, through a process of cell-cycle arrest and selection we define as a cellular crisis. This crisis is not mediated by the absence of respiration, but instead correlates with a reduction in the mitochondrial membrane potential. Analysis of cells… CONTINUE READING
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