Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence

@article{Passos2007MitochondrialDA,
  title={Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence },
  author={Jo{\~a}o F. Passos and Gabriele Saretzki and Shaheda S Ahmed and Glyn Nelson and Torsten Richter and Heiko Peters and Ilka Wappler and Matthew J Birket and Graham Harold and Karin Schaeuble and Mark A Birch-Machin and Thomas B. L. Kirkwood and Thomas von Zglinicki},
  journal={PLoS Biology},
  year={2007},
  volume={5},
  pages={437 - 447}
}
Aging is an inherently stochastic process, and its hallmark is heterogeneity between organisms, cell types, and clonal populations, even in identical environments. The replicative lifespan of primary human cells is telomere dependent; however, its heterogeneity is not understood. We show that mitochondrial superoxide production increases with replicative age in human fibroblasts despite an adaptive UCP-2-dependent mitochondrial uncoupling. This mitochondrial dysfunction is accompanied by… CONTINUE READING
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