Mitochondrial Dynamics and Motility Inside Living Vascular Endothelial Cells: Role of Bioenergetics

@article{Giedt2012MitochondrialDA,
  title={Mitochondrial Dynamics and Motility Inside Living Vascular Endothelial Cells: Role of Bioenergetics},
  author={Randy J. Giedt and Douglas R. Pfeiffer and Anastasios Matzavinos and Chiu-Yen Kao and B Rita Alevriadou},
  journal={Annals of Biomedical Engineering},
  year={2012},
  volume={40},
  pages={1903-1916}
}
The mitochondrial network is dynamic with conformations that vary between a tubular continuum and a fragmented state. The equilibrium between mitochondrial fusion/fission, as well as the organelle motility, determine network morphology and ultimately mitochondrial/cell function. Network morphology has been linked with the energy state in different cell types. In this study, we examined how bioenergetic factors affect mitochondrial dynamics/motility in cultured vascular endothelial cells (ECs… CONTINUE READING
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