Mitochondrial Dynamics: Functional Link with Apoptosis

  title={Mitochondrial Dynamics: Functional Link with Apoptosis},
  author={Hidenori Otera and Katsuyoshi Mihara},
  booktitle={International journal of cell biology},
Mitochondria participate in a variety of physiologic processes, such as ATP production, lipid metabolism, iron-sulfur cluster biogenesis, and calcium buffering. The morphology of mitochondria changes dynamically due to their frequent fusion and division in response to cellular conditions, and these dynamics are an important constituent of apoptosis. The discovery of large GTPase family proteins that regulate mitochondrial dynamics, together with novel insights into the role of mitochondrial… CONTINUE READING