Mitochondrial Disorder Associated with Newborn Cardiopulmonary Arrest

  title={Mitochondrial Disorder Associated with Newborn Cardiopulmonary Arrest},
  author={Kyunglim L Yoon and Susan G. Ernst and Cynthia Rasmussen and Elizabeth C Dooling and June R. Aprille},
  journal={Pediatric Research},
ABSTRACT: A female infant who died 2.5 d after birth with hypoglycemia, lactic acidosis, and sudden multisystem failure was studied. Biochemical studies showed complex III and IV deficiency in liver, kidney, and muscle, with muscle most severely affected. Southern blot analysis of the patient's mitochondrial DNA did not reveal any deletions. Denaturing gradient gel analysis, which detects single base changes by differences in melting behavior, showed an extra band that was not seen in… CONTINUE READING
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