Mitochondrial DNA variation in human evolution and disease.

@article{Wallace1999MitochondrialDV,
  title={Mitochondrial DNA variation in human evolution and disease.},
  author={Douglas C. Wallace and Michael D. Brown and Marie T. Lott},
  journal={Gene},
  year={1999},
  volume={238 1},
  pages={211-30}
}
Analysis of mitochondrial DNA (mtDNA) variation has permitted the reconstruction of the ancient migrations of women. This has provided evidence that our species arose in Africa about 150000 years before present (YBP), migrated out of Africa into Asia about 60000 to 70000 YBP and into Europe about 40000 to 50000 YBP, and migrated from Asia and possibly Europe to the Americas about 20000 to 30000 YBP. Although much of the mtDNA variation that exists in modern populations may be selectively… CONTINUE READING
Highly Influential
This paper has highly influenced 27 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 250 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 11 references

Adaptation and the mtDNA

  • H. Blanc, K. H. Chen, M. A. D’Amore, D. C. Wallace
  • 1997
Highly Influential
5 Excerpts

American Journal of Human Genetics

  • L. Vergani, A. Martinuzzi, V. Carelli, P. Cortelli, P. Montagna
  • 1998

Neurology 45 , 1333 – 1334 . 1992

  • A. E. Harding, M. G. Sweeney, +11 authors T. Saida
  • 1995
2 Excerpts

Genetics 140 , 285 – 302

  • W. M. Brown
  • 1991

Nature 352 , 255 – 257

  • D. Wharton, A. Josefsson, A. C. Wilson
  • 1991

Proceedings of the National Acad - Mackey , D . , Howell , N . , 1992

  • A. Di Rienzo, A. C. Wilson
  • American Journal of Human Genetics
  • 1991
1 Excerpt

of the National Academy of Sciences of the United States of America 77 , 6715 – 6719

  • N. Neckelmann, K. Li, R. P. Wade, R. Shuster, D. C. Wallace
  • 1987
1 Excerpt

Neurology 36 , 1053 – 1060

  • A. E. Harding, M. G. Sweeney, +8 authors L. Steinman
  • 1986

Similar Papers

Loading similar papers…