Mitochondrial DNA sequence alterations observed between blood and buccal cells within the same individuals having betel quid (BQ)-chewing habit.

@article{Pai2006MitochondrialDS,
  title={Mitochondrial DNA sequence alterations observed between blood and buccal cells within the same individuals having betel quid (BQ)-chewing habit.},
  author={Chung-yen Pai and Ling-ling Hsieh and Tzu-Cheng Lee and Shi-Bing Yang and Jason G Linville and Su-lien Chou and Chiou-herr Yang},
  journal={Forensic science international},
  year={2006},
  volume={156 2-3},
  pages={124-30}
}
There are hundreds of millions of betel quid (BQ) lovers widely spreading around the world. Compositions in BQ may generate reactive oxygen species, which would induce DNA damage. However, oral epithelial cells as well as blood have often been used as reference samples in comparison with the mitochondrial DNA (mtDNA) sequence of hairs. The main purpose of this study was to investigate the extent of mtDNA sequence variation in regular BQ-chewers' oral epithelial cells, and thus to evaluate the… CONTINUE READING