Mitochondrial DNA replication during differentiation of murine embryonic stem cells.

@article{FacuchoOliveira2007MitochondrialDR,
  title={Mitochondrial DNA replication during differentiation of murine embryonic stem cells.},
  author={Joao M Facucho-Oliveira and Jon Alderson and Emma C Spikings and Stuart Egginton and Justin C St John},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 22},
  pages={4025-34}
}
Oxidative phosphorylation (OXPHOS), the intracellular process that generates the majority of the ATP of a cell through the electron-transfer chain, is highly dependent on proteins encoded by the mitochondrial genome (mtDNA). MtDNA replication is regulated by the nuclear-encoded mitochondrial transcription factor A (TFAM) and the mitochondrial-specific DNA polymerase gamma, which consists of a catalytic (POLG) and an accessory (POLG2) subunit. Differentiation of pluripotent embryonic stem cells… CONTINUE READING

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