Mitochondrial DNA replication during differentiation of murine embryonic stem cells.

  title={Mitochondrial DNA replication during differentiation of murine embryonic stem cells.},
  author={Joao M Facucho-Oliveira and Jon Alderson and Emma C Spikings and Stuart Egginton and Justin C St John},
  journal={Journal of cell science},
  volume={120 Pt 22},
Oxidative phosphorylation (OXPHOS), the intracellular process that generates the majority of the ATP of a cell through the electron-transfer chain, is highly dependent on proteins encoded by the mitochondrial genome (mtDNA). MtDNA replication is regulated by the nuclear-encoded mitochondrial transcription factor A (TFAM) and the mitochondrial-specific DNA polymerase gamma, which consists of a catalytic (POLG) and an accessory (POLG2) subunit. Differentiation of pluripotent embryonic stem cells… CONTINUE READING


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Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells

Nature Clinical Practice Cardiovascular Medicine • 2007
View 5 Excerpts
Highly Influenced

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

Proceedings of the National Academy of Sciences of the United States of America • 1993
View 1 Excerpt
Highly Influenced

Mitochondrial DNA and the mammalian oocyte.

Current topics in developmental biology • 2007

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