Mitochondrial DNA replication: what we know.

  title={Mitochondrial DNA replication: what we know.},
  author={D. A. Clayton},
  journal={IUBMB life},
  volume={55 4-5},
Since the isolation and physical characterization of mammalian mitochondrial DNA (mtDNA) over 35 years ago, numerous works have been published that have examined its physical structure and properties, including its mode of replication and transcription. The established replication model posits that leading-strand replication of mammalian mtDNA begins at closely spaced, defined sites located downstream from a major transcription promoter and proceeds unidirectionally with displacement of the… CONTINUE READING

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