Mitochondrial DNA repair of oxidative damage in mammalian cells.

  title={Mitochondrial DNA repair of oxidative damage in mammalian cells.},
  author={Vilhelm A. Bohr and Tinna Stevnsner and Nadja Cristhina de Souza-Pinto},
  volume={286 1},
Nuclear and mitochondrial DNA are constantly being exposed to damaging agents, from endogenous and exogenous sources. In particular, reactive oxygen species (ROS) are formed at high levels as by-products of the normal metabolism. Upon oxidative attack of DNA many DNA lesions are formed and oxidized bases are generated with high frequency. Mitochondrial DNA has been shown to accumulate high levels of 8-hydroxy-2'-deoxyguanosine, the product of hydroxylation of guanine at carbon 8, which is a… CONTINUE READING

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