Mitochondrial DNA polymorphism: its role in longevity of the Irish population.

  title={Mitochondrial DNA polymorphism: its role in longevity of the Irish population.},
  author={Owen A. Ross and Rose McCormack and Martin David Curran and R Alistair Duguid and Yvonne A Barnett and Irene Maeve Rea and Derek Middleton},
  journal={Experimental gerontology},
  volume={36 7},
The mtDNA genome has been implicated as playing a pivotal role in determining the longevity and success of the human lifespan. A PCR-RFLP methodology was used to identify polymorphic restriction enzyme sites within a 2643 bp region of the mtDNA genome and a table of genetic haplotypes for a healthy aged and a younger control cohort of patients was constructed. Forty-six different mtDNA haplotypes and 11 groups of related haplotypes were identified across the two age groups but statistical… CONTINUE READING
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