Mitochondrial DNA mutators

In this article we review our current knowledge of the mechanisms by which point mutations arise in the mitochondrial DNA (mtDNA) of Saccharomyces cerevisiae and discuss to what extent these mechanisms operate in human mtDNA mutagenesis. The 3′–5′ exonuclease proofreading activity of Pol γ ensures accuracy of mtDNA replication in both yeast and humans… CONTINUE READING