Mitochondrial DNA mutations in human colonic crypt stem cells.

@article{Taylor2003MitochondrialDM,
  title={Mitochondrial DNA mutations in human colonic crypt stem cells.},
  author={Robert W Taylor and Martin J. Barron and Gillian M. Borthwick and Amy Gospel and Patrick F. Chinnery and David C. Samuels and Geoffrey A. Taylor and Stefan M Plusa and Stephanie Needham and Laura C. Greaves and Thomas B. L. Kirkwood and Douglass Matthew Turnbull},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={112 9},
  pages={1351-60}
}
The mitochondrial genome encodes 13 essential subunits of the respiratory chain and has remarkable genetics based on uniparental inheritance. Within human populations, the mitochondrial genome has a high rate of sequence divergence with multiple polymorphic variants and thus has played a major role in examining the evolutionary history of our species. In recent years it has also become apparent that pathogenic mitochondrial DNA (mtDNA) mutations play an important role in neurological and other… CONTINUE READING
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