Mitochondrial DNA mutations in human cancer

@article{Chatterjee2006MitochondrialDM,
  title={Mitochondrial DNA mutations in human cancer},
  author={Aditi Chatterjee and Elizabeth Mambo and David Sidransky},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={4663-4674}
}
Somatic mitochondrial DNA (mtDNA) mutations have been increasingly observed in primary human cancers. As each cell contains many mitochondria with multiple copies of mtDNA, it is possible that wild-type and mutant mtDNA can co-exist in a state called heteroplasmy. During cell division, mitochondria are randomly distributed to daughter cells. Over time, the proportion of the mutant mtDNA within the cell can vary and may drift toward predominantly mutant or wild type to achieve homoplasmy. Thus… CONTINUE READING
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