Mitochondrial DNA mutations associated with aminoglycoside induced ototoxicity

@inproceedings{Gao2017MitochondrialDM,
  title={Mitochondrial DNA mutations associated with aminoglycoside induced ototoxicity},
  author={Zewen Gao and Ye Chen and Min-Xin Guan},
  booktitle={Journal of otology},
  year={2017}
}
Aminoglycosides (AmAn) are widely used for their great efficiency against gram-negative bacterial infections. However, they can also induce ototoxic hearing loss, which has affected millions of people around the world. As previously reported, individuals bearing mitochondrial DNA mutations in the 12S rRNA gene, such as m.1555A>G and m.1494C>T, are more prone to AmAn-induced ototoxicity. These mutations cause human mitochondrial ribosomes to more closely resemble bacterial ribosomes and enable a… CONTINUE READING

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