Mitochondrial DNA mutations activate programmed cell survival in the mouse heart.

@article{Zhang2005MitochondrialDM,
  title={Mitochondrial DNA mutations activate programmed cell survival in the mouse heart.},
  author={Dekui Zhang and Justin L Mott and Shin-Wen Chang and Melissa Aileene Stevens and Peter C Mikolajczak and Hans Zassenhaus},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={288 5},
  pages={
          H2476-83
        }
}
Increased frequencies of mitochondrial DNA (mtDNA) mutations characterize the aging heart and are also found in idiopathic dilated cardiomyopathy and end-stage heart failure. The pathogenic potential of such mutations is unclear. Transgenic mice showing accelerated accumulation of mtDNA mutations and dilated cardiomyopathy due to expression of an error-prone mtDNA polymerase specifically in the heart were characterized by Western blot analysis and immunohistochemistry for the levels of pro- and… CONTINUE READING

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