Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.

  title={Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.},
  author={Gregory C. Kujoth and Asimina Hiona and Thomas D. Pugh and Shinichi Someya and Karin Panzer and Stephanie Eva Wohlgemuth and Tim Hofer and Arnold Young Seo and Ryan Sullivan and Wendy A Jobling and Jason D. Morrow and Holly van Remmen and John M. Sedivy and Tatsuya Yamasoba and Masaru Tanokura and Richard Weindruch and Christiaan Leeuwenburgh and Tomas A. Prolla},
  volume={309 5733},
Mutations in mitochondrial DNA (mtDNA) accumulate in tissues of mammalian species and have been hypothesized to contribute to aging. We show that mice expressing a proofreading-deficient version of the mitochondrial DNA polymerase g (POLG) accumulate mtDNA mutations and display features of accelerated aging. Accumulation of mtDNA mutations was not associated with increased markers of oxidative stress or a defect in cellular proliferation, but was correlated with the induction of apoptotic… CONTINUE READING
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