Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells

  title={Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells},
  author={Eugene Debs Robin and R J Wong},
  journal={Journal of Cellular Physiology},
  • E. RobinR. Wong
  • Published 1 September 1988
  • Biology
  • Journal of Cellular Physiology
A new biochemical method for estimating the virtual number of mitochondria (mt) per cell was developed and used together with a plasmid probe to measure mt DNA/mitochondrion and mt DNA/cell. These methods were used in five cell types from four mammalian species. Mt DNA/mitochondrion was essentially constant in all cell types (mean 2.6 ± 0.30 SE mitochondrial DNA molecules/mt). Mt DNA molecules/cell encompassed an eight‐fold range between various cell types (low 220 ± 6.2; high 1,720 ± 162 mt… 

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