Mitochondrial DNA metabolism targeting drugs.

@article{Rowe2001MitochondrialDM,
  title={Mitochondrial DNA metabolism targeting drugs.},
  author={Thomas C. Rowe and Volkmar Weissig and Jeffrey W. Lawrence},
  journal={Advanced drug delivery reviews},
  year={2001},
  volume={49 1-2},
  pages={
          175-87
        }
}
Numerous drugs are known to deplete mitochondrial DNA (mtDNA) from mammalian cells. These include DNA polymerase gamma and type II topoisomerase inhibitors, lipophilic cationic compounds, and DNA intercalating and non intercalating agents. The effects of these drugs on mtDNA metabolism will be discussed and potential mechanisms underlying their depletion of mtDNA presented. 

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