Mitochondrial DNA maintenance and bioenergetics.

  title={Mitochondrial DNA maintenance and bioenergetics.},
  author={Jeffrey A Stuart and Melanie F Brown},
  journal={Biochimica et biophysica acta},
  volume={1757 2},
Oxidative phosphorylation requires assembly of the protein products of both mitochondrial and of nuclear genomes into functional respiratory complexes. Cellular respiration can be compromised when mitochondrial DNA (mtDNA) sequences are corrupted. Oxidative damage resulting from reactive oxygen species (ROS) produced during respiration is probably a major source of mitochondrial genomic instability leading to respiratory dysfunction. Here, we review mechanisms of mitochondrial ROS production… CONTINUE READING
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