Mitochondrial DNA-like sequences in the nucleus (NUMTs): insights into our African origins and the mechanism of foreign DNA integration.

@article{Mishmar2004MitochondrialDS,
  title={Mitochondrial DNA-like sequences in the nucleus (NUMTs): insights into our African origins and the mechanism of foreign DNA integration.},
  author={Dan Mishmar and Eduardo Ruiz-Pesini and Martin Brandon and Douglas C. Wallace},
  journal={Human mutation},
  year={2004},
  volume={23 2},
  pages={125-33}
}
Nuclear mitochondrial DNA sequences (NUMTs) are common in eukaryotes. However, the mechanism by which they integrate into the nuclear genome remains a riddle. We analyzed 247 NUMTs in the human nuclear DNA (nDNA), along with their flanking regions. This analysis revealed that some NUMTs have accumulated many changes, and thus have resided in the nucleus a long time, while others are >94% similar to the reference human mitochondrial DNA (mtDNA), and thus must be recent. Among the latter, two… CONTINUE READING
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