Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans

  title={Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans},
  author={Giovanna de Benedictis and Giuseppina Rose and Giuseppina Carrieri and Maria De Luca and Emiliana Falcone and Giuseppe Passarino and Massimiliano Bonaf{\`e} and Daniela Monti and Giovannella Baggio and Stefano Bertolini and Daniela Mari and Rosario Mattace and Claudio Franceschi},
  journal={The FASEB Journal},
  pages={1532 - 1536}
Mitochondrial DNA (mtDNA) is characterized by high variability, maternal inheritance, and absence of recombination. Studies of human populations have revealed ancestral associated polymorphisms whose combination defines groups of mtDNA types (haplogroups) that are currently used to reconstruct human evolution lineages. We used such inherited mtDNA markers to compare mtDNA population pools between a sample of individuals selected for successful aging and longevity (212 subjects older than 100… 

Inherited Variability of the Mitochondrial Genome and Successful Aging in Humans

The results obtained by screening mtDNA haplogroups in about 800 Italians of different ages agree with the hypothesis that the inherited variability of the mitochondrial genome is associated with the chance of successful aging and longevity in humans.

Mitochondrial DNA polymorphisms associated with longevity in a Finnish population

The data appear to favour the presence of advantageous polymorphisms and support a role for mitochondria and mtDNA in the degenerative processes involved in ageing and suggest an association between certain mtDNA haplogroups or haplogroup clusters and longevity.

Association of the mitochondrial DNA haplogroup J with longevity is population specific

It is shown that, in this population, haplogroup J does not play a significant role in longevity, and the association of mtDNA inherited variability with longevity is population specific.

Mitochondrial Polymorphisms Are Associated Both with Increased and Decreased Longevity

The data confirm that mtDNA make up affects longevity, and indicate that the time period in which a person was born had a much greater impact on longevity than presence or absence of a marker.

Are mitochondrial haplogroups associated with extreme longevity? A study on a Spanish cohort

The data confirm that the potential effects of mitochondrial haplogroups on human longevity might be population/geographic specific, with important differences between studies arising from the different living environment and ethnic background of the study cohorts.

Association of Mitochondrial DNA Haplogroups with Exceptional Longevity in a Chinese Population

The association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population support the effects of mtDNA haplog groups on the prevalence of extreme longevity.

A Mitochondrial Haplogroup is Associated with Decreased Longevity in a Historic New World Population

In support of previous suggestions that the link between mtDNA haplogroups and longevity is specific to the population being studied, an association between haplogroup C and decreased longevity is found, and the lifetime reproductive success and the number of grandchildren produced via a daughter of women with haplogsroup C are not reduced.



Mitochondrial DNA sequence variation in human evolution and disease.

  • D. Wallace
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1994
All extant mutations of this class are recent and associated with more devastating diseases of young adults and children and provide a molecular clock that measures the authors' age and may cause a progressive decline in tissue energy output that could precipitate the onset of degenerative diseases in individuals harboring inherited deleterious mutations.

Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle.

The data imply that a wide spectrum of mtDNA rearrangements accumulate in old individuals, which correlates with the marked age related decrease in OXPHOS capacity observed in post-mitotic tissues.

Classification of European mtDNAs from an analysis of three European populations.

The conclusion that most haplogroups observed in Europe are Caucasoid-specific, and that at least some of them occur at varying frequencies in different Caucasoid populations, is supported.

Maternal inheritance of human mitochondrial DNA.

The results of this study demonstrate that human mitochondrial DNA is maternally inherited and represents a convenient way to obtain data on mitochondrial DNA variation in both individuals and populations.

Analysis of mtDNA variation in African populations reveals the most ancient of all human continent-specific haplogroups.

Comparison of the intrapopulation sequence divergence in African and non-African populations confirms that African populations exhibit the largest extent of mtDNA variation, a result that further supports the hypothesis that Africans represent the most ancient human group and that all modern humans have a common and recent African origin.

Southeast Asian mitochondrial DNA analysis reveals genetic continuity of ancient mongoloid migrations.

Human mitochondrial DNAs from 153 independent samples encompassing seven Asian populations were surveyed for sequence variation using the polymerase chain reaction (PCR), restriction endonuclease analysis and oligonucleotide hybridization, indicating a Southern Mongoloid origin of Asians.

mtDNA and the origin of Caucasians: identification of ancient Caucasian-specific haplogroups, one of which is prone to a recurrent somatic duplication in the D-loop region.

The sequence divergence of these haplogroups indicates that they arose early in Caucasian radiation and gave raise to modern European mtDNAs, suggesting that Homo sapiens sapiens displaced H. s.

Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2)

The data is consistent with an association between the THO locus and longevity, and the latter loci do not affect inter-individual variability in life expectancy.

Molecular genetic aspects of human mitochondrial disorders.

This review focuses on mutations of mitochondrial DNA (mtDNA) which are an important cause of mitochondrial disorders in humans and are also associated with common neurodegenerative disorders and