Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans

@article{deBenedictis1999MitochondrialDI,
  title={Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans},
  author={Giovanna de Benedictis and Giuseppina Rose and Giuseppina Carrieri and Maria De Luca and Emiliana Falcone and Giuseppe Passarino and Massimiliano Bonaf{\`e} and Daniela Monti and Giovannella Baggio and Stefano Bertolini and Daniela Mari and Rosario Mattace and Claudio Franceschi},
  journal={The FASEB Journal},
  year={1999},
  volume={13},
  pages={1532 - 1536}
}
Mitochondrial DNA (mtDNA) is characterized by high variability, maternal inheritance, and absence of recombination. Studies of human populations have revealed ancestral associated polymorphisms whose combination defines groups of mtDNA types (haplogroups) that are currently used to reconstruct human evolution lineages. We used such inherited mtDNA markers to compare mtDNA population pools between a sample of individuals selected for successful aging and longevity (212 subjects older than 100… Expand
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