Mitochondrial DNA haplogroups modulate the serum levels of biomarkers in patients with osteoarthritis.

@article{RegoPrez2010MitochondrialDH,
  title={Mitochondrial DNA haplogroups modulate the serum levels of biomarkers in patients with osteoarthritis.},
  author={Ignacio Rego-P{\'e}rez and Mercedes Fern{\'a}ndez-Moreno and Michelle A Deberg and Sonia D. P{\'e}rtega and Carlos Fen{\'a}ndez-L{\'o}pez and Natividad Oreiro and Yves Edgard Henrotin and Francisco J Blanco},
  journal={Annals of the rheumatic diseases},
  year={2010},
  volume={69 5},
  pages={910-7}
}
OBJECTIVE To analyse the influence of mitochondrial DNA (mtDNA) haplogroups on serum levels of molecular biomarkers in patients with osteoarthritis (OA). METHODS Serum levels of molecular biomarkers of cartilage metabolism (collagen type II markers: C-terminal neoepitope generated by the collagenase-mediated cleavage of collagen type II triple helix (C2C), collagen type II (Coll2-1, and its nitrated form, Coll2-1NO(2)), procollagen type II (CPII)), synovial metabolism (hyaluronic acid (HA… CONTINUE READING
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