Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies.

@article{Chinnery2000MitochondrialDH,
  title={Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies.},
  author={Patrick F. Chinnery and Geoffrey A. Taylor and Neil Howell and Robert Andrews and Christopher M Morris and Robert W Taylor and Ian G. McKeith and Robert H. Perry and James A. Edwardson and Douglass Matthew Turnbull},
  journal={Neurology},
  year={2000},
  volume={55 2},
  pages={302-4}
}
The authors analyzed the relationship between nuclear genetic risk factors (apolipoprotein E genotype) and mitochondrial DNA (mtDNA) sequence variants in pathologically proved cases of AD (n = 185), dementia with Lewy bodies (DLB; n = 84), and control subjects (n = 179). Specific European mtDNA haplogroups and the A4336G mutation were not associated with an increased risk of AD. mtDNA haplogroup H was overrepresented in the DLB patients when compared with control subjects. Additional studies… CONTINUE READING

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