Mitochondrial DNA haplogroup T is associated with coronary artery disease and diabetic retinopathy: a case control study

@article{Kofler2008MitochondrialDH,
  title={Mitochondrial DNA haplogroup T is associated with coronary artery disease and diabetic retinopathy: a case control study},
  author={Barbara Kofler and Edith E. Mueller and Waltraud Eder and Olaf H Stanger and Richard A. Maier and Martin Weger and Anton Haas and Robert Winker and Otto Schmut and Bernhard Paulweber and Bernhard Iglseder and Wilfried Renner and Martina Wiesbauer and Irene Aigner and Danijela Santic and Franz A Zimmermann and Johannes A Mayr and Wolfgang Sperl},
  journal={BMC Medical Genetics},
  year={2008},
  volume={10},
  pages={35 - 35}
}
There is strong and consistent evidence that oxidative stress is crucially involved in the development of atherosclerotic vascular disease. Overproduction of reactive oxygen species (ROS) in mitochondria is an unifying mechanism that underlies micro- and macrovascular atherosclerotic disease. Given the central role of mitochondria in energy and ROS production, mitochondrial DNA (mtDNA) is an obvious candidate for genetic susceptibility studies on atherosclerotic processes. We therefore examined… CONTINUE READING
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